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データギャラリー: 光学イメージング

Vasculature NiraWave C
NiraWave™ C optical imaging of mouse ear vessels
NiraWave™ C is formulated from the clinically proven indocyanine green agent for use in animal imaging. It is a versatile dye that is used for angiography of the eye, organ perfusion, rheumatology diagnostics, and photodynamic therapy research. Mouse ear optical angiography with NiraWave C highlights vascular structures.
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Vasculature NiraWave M
NiraWave™ M optical angiography of mouse ear vessels
NiraWave™ M is a unique micellar formulation of NiraWave C with a long circulation time ideal for optical angiography and the study of vascular leakage in inflammation (e.g. rheumatic disease) and tumors. It has a high apparent molecular weight and stays confined in healthy vasculature for more than one hour, while it passes through fenestrated blood vessels. Mouse ear optical angiography with NiraWave M shows superior circulation time over ICG standard dye.
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Inflammation NiraWave M
NiraWave™ M inflammation imaging
NiraWave™ M is a unique micellar formulation of NiraWave C with a long circulation time ideal for optical angiography and the study of vascular leakage in inflammation (e.g. rheumatic disease) and tumors. It has a high apparent molecular weight and stays confined in healthy vasculature for more than one hour, while it passes through fenestrated blood vessels. Inflammation imaging in a rheumatoid arthritis rat model (right) versus the control animal (left) based on NiraWave M vascular leakage.
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Vasculature NiraWave nano 780
NiraWave™ nano 780 nanoparticle optical angiography
NiraWave™ nano 780 is a nanoparticulate optical imaging agent for the visualization of vascular fine structure as well as angiogenic processes in tumors and inflammation. It provides a broad excitation range, a high quantum yield and best possible tissue penetration due to fluorescence in the near-infrared range. Left: Optical angiography in mouse injected with NiraWave nano 780. The fine structure of blood vessels is clearly visible, for example, in the hind limbs. Right: Color-coded image of the same animal showing a vascularized tumor in the hind limb.
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Tumor A549 NiraWave M
NiraWave™ M tumor imaging
Whole-body NIR fluorescence image of a A549 tumor bearing mouse at 9 h after injection of NiraWave™ M. (Courtesy of Michael Heß, Julius-Maximilians University Würzburg, Germany)
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